Cart
sales@molnova.com
PIN1 inhibitor API-1
CAS No. 680622-70-2
PIN1 inhibitor API-1 ( —— )
Catalog No. M24694 CAS No. 680622-70-2
PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 177 | In Stock |
|
| 10MG | 337 | In Stock |
|
| 25MG | 482 | In Stock |
|
| 50MG | 696 | In Stock |
|
| 100MG | 897 | In Stock |
|
| 200MG | 1314 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePIN1 inhibitor API-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionPIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development.
-
DescriptionPIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorPin1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number680622-70-2
-
Formula Weight366.3
-
Molecular FormulaC15H13F3N6O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:250 mg/mL (682.50 mM; Need ultrasonic)
-
SMILESC1=CC(=CC=C1CNC(=O)C(F)(F)F)COC2=NC(=NC3=C2NC=N3)N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Pu W, et al. Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellularcarcinoma development. Hepatology. 2018 Aug;68(2):547-560.
molnova catalog
related products
-
Cefaclor
Cefaclor is a cephalosporin antibiotic.
-
CADD522
CADD522 is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activityCADD522 is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding( IC50 of 10 nM), has antitumor activity.
-
1-Furfurylpyrrole
1-Furfurylpyrrole is a potential contributor of flavor and aroma to popcorn.
